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M65 EpiDeath ELISA (Prod. No. 10040)
The M65 EpiDeath ELISA is the next generation of Peviva's biomarkers. It is intended for the quantitative detection of keratin 18 (K18) present in cell culture supernatants, human serum, human plasma or other body fluids after it has been released from dying cells into the extracellular compartment. The assays offers the opportunity to quantify total cell death (due to apoptosis and necrosis) of K18 positive (epithelial) cells.
The M65 EpiDeath ELISA, when used in combination with the M30 Apoptosense ELISA (which specifically measures apoptosis), allows to distinguish different forms of epithelial cell death as both assay are standardised against the identical reference (Kramer et al., 2004).
The M65 EpiDeath ELISA is a modified version of the M65 ELISA and is intended for the samples with high Keratin 18 plasma and serum levels (e.g. sepsis, GvHD and liver toxicity such as DILI or ALF).
Further information about the similarities and differences between these two assays is available on PEVIVA's website Comparison between M65 EpiDeath ELISA and M65 ELISA.
» Click here for M65 EpiDeath® ELISA Instructions for Use (Manual) Prod. No. #10040
» Click here for M65 EpiDeath® ELISA Fact Sheet #10040
Oncology (Cytotoxic & Biologics Drugs)
Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease. (PUBMED Link, Abstract)
Cell Death Biomarkers as Early Predictors for Hepatic Dysfunction in Patients After Orthotopic Liver Transplantation. (PUBMED LINK Abstract)