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M30 CytoDEATHTM Monocloncal Antibody (caspase-cleaved Cytokeratin 18)
Prod. No. 10700 (unconjugated); 10750 (Biotin); 10800 (FITC); 10830 (Orange)
Apoptosis proceeds through cleavage of various intracellular proteins. The proteases which mediate this process are referred to as caspases. One important caspase substrate is the intermediate filament protein keratin 18 (K18, Cytokeratin 18 or CK18) (Caulin et al., 1997), expressed in cells of simple epithelia.
Oncology (Cytotoxic & Biologics Drugs)
Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease. (PUBMED Link, Abstract)
Cell Death Biomarkers as Early Predictors for Hepatic Dysfunction in Patients After Orthotopic Liver Transplantation. (PUBMED LINK Abstract)