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M30-Apoptosense is an enzyme-linked immunosorbent assay (ELISA) for the quantitative detection of caspase-cleaved Keratin-18 (ccK18, K18F, K18Asp396-NE: M30 neo-epitope) levels in cytosolic cell extracts, cell culture supernatants, human serum or plasma or other body fluids. The M30-Apoptosense ELISA uses the M30 antibody which is specific to this K18 cleavage site and does not react with viable or necrotic cells.
The M30-Apoptosense ELISA measures the accumulation of a caspase-generated product resulting in an unmatched sensitivity thus allowing the tracing of apoptotic cells of epithelial origin in patient plasma/serum.
Important applications include clinical drug development in oncology and hepatology.
» Click here for M30 Apoptosense® ELISA Prod. No. #10011 Hepatology Fact Sheet
» Click here for M30 Apoptosense® ELISA Prod. No. #10011 Drug Development Fact Sheet
» Click here to buy M30 Apoptosense® ELISA
Oncology (Cytotoxic & Biologics Drugs)
Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease. (PUBMED Link, Abstract)
Cell Death Biomarkers as Early Predictors for Hepatic Dysfunction in Patients After Orthotopic Liver Transplantation. (PUBMED LINK Abstract)